Concepedia

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Janakiraman Krishnamurthy, Norman E. Sharpless, Sheng Ding, Wei Feng,

Nature Medicine · 2015 · 1.8K citations · 28 references

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28

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.4K citations

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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.6K citations · Full text

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers, Joel D. Leverson, Erwin R. Boghaert et al. · Nature Medicine · 2013 · 3K citations

, , +10

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

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