Senescent Cell Accumulation is a biological phenomenon characterized by the progressive retention of metabolically active but non-proliferative cells that exhibit a distinct secretory profile, resulting from persistent DNA damage, oxidative stress, or inflammatory signals within chronically impaired tissue microenvironments.
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Hallmarks of Cancer: New Dimensions
Cancer Discovery · 2022 · 9.1K citations · Full text
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Jianhui Chang, Yingying Wang, Lijian Shao et al. · Nature Medicine · 2015 · 1.8K citations
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