Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine Schiff bases

Abstract

In this work, a series of histamine Schiff bases H(1-20) were synthesized by reacting histamine and substituted aldehydes A(1-20). The compounds were assayed for antioxidant properties by using different bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of the compounds showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with % inhibition of 97.03 and 93.64, respectively.