Concepedia

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

Amanda Kahn-Kirby, Akiko Amagata, Céline I. Maeder, Janet J. Mei, Steve Sideris, Yuko Kosaka, A. Scott Hinman, Stephanie Malone, Joel Bruegger, Leslie Wang,

PLoS ONE · 2019 · 96 citations · 55 references

DOIFull text

Open access

Abstract

These findings support the continued clinical evaluation of EPI-743 as a therapeutic agent for PCH6 and other mitochondrial diseases with associated epilepsy.

References

55

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 17K citations · Full text

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Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, Rohitha Sriramaratnam, Matthew Welsch et al. · Cell · 2014 · 7.1K citations · Full text

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y. Tyurina et al. · Nature Chemical Biology · 2016 · 3.8K citations · Full text

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

José Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth et al. · Nature Cell Biology · 2014 · 3.5K citations

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan, Gaowei Mao, Feng Qu et al. · Nature Chemical Biology · 2016 · 2.7K citations · Full text

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