Antioxidant Determinations by the Use of a Stable Free Radical

Marsden S. Blois

Nature

BiochemistryMedicineRadical (Chemistry)Analytical ChemistryStable Free Radical +5

Glutamate neurotoxicity and diseases of the nervous system

Dennis W. Choi

Neuron

Neurodegenerative DiseasesNeurophysiologyNeuropharmacologyNeuroprotectionNeurology +6

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, +13

Cell

Mitochondrial FunctionMedicineNatural SciencesMolecular BiologyMolecular Genetics +4

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso, +8

Proceedings of the National Academy of Sciences

Mitochondrial GlutaminolysisMolecular BiologyMetabolic RemodelingCellular PhysiologyTranscriptional Regulation +21

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell

Chemistry & Biology

Tumor BiologyNonapoptotic Cell DeathOncogenic AgentMedicineApoptosis +8

A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

Jason Moffat, Dorre A. Grueneberg, Xiaoping Yang, +16

Cell

Viral ReplicationMolecular VirologyImmunologyMouse Genes AppliedLentiviral Rnai Library +7

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor, +11

Nature

Redox SignalingSignal TransductionMedicineApoptosisCell Death +10

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L. Lessnick, William C. Hahn, +1

Cancer Cell

Tumor BiologyOncogenic AgentMedicinePharmacologyGenotype-selective Antitumor Agents +7

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin, +7

Nature

BiochemistryMitochondrial FunctionOrganelle DynamicTumour CellsCell Proliferation +5

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

Hideyo Sato, Michiko Tamba, Tetsuro Ishii, +1

Journal of Biological Chemistry