Rohitha Sriramaratnam

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, Rohitha Sriramaratnam, Matthew Welsch et al. · Cell · 2014 · 7.5K citations · Full text

Life Sciences, Molecular Biology, Oncology +12

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

Georg Petzold, Pablo Gaínza, Stefano Annunziato et al. · Science · 2025 · 71 citations

Life Sciences, Biochemistry, Molecular Biology +14

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

Chiara Borsari, Erhan Keleş, Jacob A. McPhail et al. · Journal of the American Chemical Society · 2022 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

(<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

Denise Rageot, Thomas Bohnacker, Erhan Keleş et al. · Journal of Medicinal Chemistry · 2019 · 55 citations · Full text

Medicine, Oncology, Pharmacology +14

4-(Difluoromethyl)-5-(4-((3<i>R</i>,5<i>S</i>)-3,5-dimethylmorpholino)-6-((<i>R</i>)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders

Chiara Borsari, Erhan Keleş, Denise Rageot et al. · Journal of Medicinal Chemistry · 2020 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14