Jacob A. McPhail

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Nobutaka Kato, Eamon Comer, Tomoyo Sakata‐Kato et al. · Nature · 2016 · 266 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Christel Brunschwig, Nina Lawrence, Dale Taylor et al. · Antimicrobial Agents and Chemotherapy · 2018 · 136 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

Florentine U. Rutaganira, M.L. Fowler, Jacob A. McPhail et al. · Journal of Medicinal Chemistry · 2016 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

Chiara Borsari, Erhan Keleş, Jacob A. McPhail et al. · Journal of the American Chemical Society · 2022 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

(<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

Denise Rageot, Thomas Bohnacker, Erhan Keleş et al. · Journal of Medicinal Chemistry · 2019 · 55 citations · Full text

Medicine, Oncology, Pharmacology +14