A rapid and versatile tool for genomic engineering in Lactococcus lactis

One-step inactivation of chromosomal genes in <i>Escherichia coli</i> K-12 using PCR products

Kirill A. Datsenko, Barry L. Wanner · Proceedings of the National Academy of Sciences · 2000 · 15K citations · Full text

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau et al. · Science · 2007 · 6.2K citations

Phage-resistance Phenotype, Genetics, Bacteriophage +12

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell · 2013 · 3.3K citations · Full text

Rna-guided Crispr Cas9, Genetics, Molecular Biology +7

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

Elitza Deltcheva, Krzysztof Chylinski, Cynthia M. Sharma et al. · Nature · 2011 · 2.5K citations · Full text

Natural Sciences, Genetics, Crispr Rna Maturation +9

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang, David Bikard, David Cox et al. · Nature Biotechnology · 2013 · 2.5K citations · Full text

Crispr-cas Systems, Genetic Engineering, Molecular Biology +5