Concepedia

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Jianling Xie, Viviane S. Alves, Tobias von der Haar, Louise V. O’Keefe, Roman V. Lenchine, Kirk B. Jensen, Rui Liu, Mark J. Coldwell, Xuemin Wang, Christopher G. Proud

Current Biology · 2019 · 88 citations · 48 references

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48

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Georg Dietzl, Doris Chen, Frank Schnorrer et al. · Nature · 2007 · 2.8K citations

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman, Jennifer M. A. Tullet, Daniela Wieser et al. · Science · 2009 · 1.1K citations

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Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

D. Allan Drummond, Claus O. Wilke · Cell · 2008 · 1.1K citations · Full text

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