Concepedia

Carnosol, a dietary diterpene from rosemary (Rosmarinus officinalis) activates Nrf2 leading to sestrin 2 induction in colon cells

Miao Yan, Bhaskar Vemu, Jacob P. Veenstra, Sakina Petiwala, Jeremy J. Johnson

Integrative Molecular Medicine · 2018 · 21 citations · 25 references

DOIFull text

Open access

Abstract

Based on these observations carnosol modulates the PERK and Nrf2 pathways along with increased expression of sestrin-2, a known stress inducible antioxidant.

References

25

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Sara B. Cullinan, Donna Zhang, Mark Hannink et al. · Molecular and Cellular Biology · 2003 · 1.2K citations · Full text

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Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid

Okezie I. Aruoma, Barry Halliwell, Robert Aeschbach et al. · Xenobiotica · 1992 · 511 citations

Carnosic acid, a <i>catechol‐type</i> electrophilic compound, protects neurons both <i>in vitro</i> and <i>in vivo</i> through activation of the Keap1/Nrf2 pathway via <i>S‐</i>alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh et al. · Journal of Neurochemistry · 2007 · 377 citations · Full text

Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages

Ai-Hsiang Lo, Yu‐Chih Liang, Shoei‐Yn Lin‐Shiau et al. · Carcinogenesis · 2002 · 290 citations

Keap1 Regulates the Oxidation-Sensitive Shuttling of Nrf2 into and out of the Nucleus via a Crm1-Dependent Nuclear Export Mechanism

Michaella Velichkova, Tama Hasson · Molecular and Cellular Biology · 2005 · 236 citations · Full text