Carnosic acid, a <i>catechol‐type</i> electrophilic compound, protects neurons both <i>in vitro</i> and <i>in vivo</i> through activation of the Keap1/Nrf2 pathway via <i>S‐</i>alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh, +10

Journal of Neurochemistry

Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons

Takumi Satoh, Daisaku Nakatsuka, Yasuyoshi Watanabe, +3

Neuroscience Letters

Reductive StressCortical NeuronsSignal TransductionMedicineReceptor Tyrosine Kinase +11

Antiobesity Effects of<i>Bifidobacterium breve</i>Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

Shizuki Kondo, Jin‐zhong Xiao, Takumi Satoh, +7

Bioscience Biotechnology and Biochemistry

Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells

Takumi Satoh, Yasushi Enokido, Hitoshi Aoshima, +2

Journal of Neuroscience Research

Functional similarity of HIV-I rev and HTLV-I rex proteins: Identification of a new nucleolar-targeting signal in rev protein

Satoshi Kubota, Haruhiko Siomi, Takumi Satoh, +3

Biochemical and Biophysical Research Communications

Viral ReplicationMedicineNatural SciencesHuman RetrovirusImmunology +11

Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism

Toshiyuki Takahashi, Takahito Tabuchi, Yosei Tamaki, +3

Biochemical and Biophysical Research Communications

BiochemistryMedicineLipid PeroxidationPhysiologyMetabolic Regulation +6

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners

Takumi Satoh, Masanori Izumi, Yuki Inukai, +8

Neuroscience Letters

BiochemistryNeurophysiologyMedicineNeuronal Ht22 CellsFree Carboxylic Acid- +8

Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells

Hitoshi Aoshima, Takumi Satoh, Naoto Sakai, +4

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

InflammationOxysterolBiochemistryLipid Hydroperoxide-triggered ApoptosisMedicine +9

Generation of reactive oxygen species, release of l-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture

Yasuyuki Ishikawa, Takumi Satoh, Yasushi Enokido, +3

Brain Research

Oxygen-induced ApoptosisDevelopmental BiologyNeurophysiologyEmbryonic Hippocampal NeuronsMedicine +10

Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate

Takumi Satoh, Stuart A. Lipton

F1000Research