Kunio Kosaka

Carnosic acid, a <i>catechol‐type</i> electrophilic compound, protects neurons both <i>in vitro</i> and <i>in vivo</i> through activation of the Keap1/Nrf2 pathway via <i>S‐</i>alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh et al. · Journal of Neurochemistry · 2007 · 377 citations · Full text

Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism

Toshiyuki Takahashi, Takahito Tabuchi, Yosei Tamaki et al. · Biochemical and Biophysical Research Communications · 2009 · 125 citations

Biochemistry, Medicine, Lipid Peroxidation +8

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners

Takumi Satoh, Masanori Izumi, Yuki Inukai et al. · Neuroscience Letters · 2008 · 118 citations

Biochemistry, Neurophysiology, Medicine +10

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

Kunio Kosaka, Junsei Mimura, Ken Itoh et al. · The Journal of Biochemistry · 2009 · 93 citations

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models

Stuart A. Lipton, Tayebeh Rezaie, Anthony Nutter et al. · Cell Death and Disease · 2016 · 87 citations · Full text