A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 1.9K citations

Oncogene-induced Senescence, Chromatin, Genome Instability +11

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang, Yingying Wang, Lijian Shao et al. · Nature Medicine · 2015 · 1.7K citations · Full text

Developmental Biology, Medicine, Stem Cell Mobilization +13

Cellular Senescence in Aging Primates

Utz Herbig, Mark Ferreira, Laura Condel et al. · Science · 2006 · 1.1K citations

Lifespan Extension, Replicative Senescence, Aging +12

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Janet R. Sparrow, Kazuyoshi Nakanishi, Craig A. Parish · PubMed · 2000 · 574 citations

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

EA Georgakopoulou, K Tsimaratou, Konstantinos Evangelou et al. · Aging · 2012 · 379 citations · Full text