Phosphorylation of serine 305 in tau inhibits aggregation

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Cryo-EM structures of tau filaments from Alzheimer’s disease

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He et al. · Nature · 2017 · 2.1K citations

Life Sciences, Molecular Biology, Neuroscience +16

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

Michel Goedert, Ross Jakes, M. G. Spillantini et al. · Nature · 1996 · 1K citations

Life Sciences, Molecular Biology, Neuroscience +15

Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ( ³⁰⁶ VQIVYK ³¹¹ ) forming β structure

Martin von Bergen�, Peter Friedhoff, Jacek Biernat et al. · Proceedings of the National Academy of Sciences · 2000 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

Alejandra del C. Alonso, Tanweer Zaidi, Michal Novák et al. · Proceedings of the National Academy of Sciences · 2001 · 973 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17