Concepedia

PKM2 is not required for pancreatic ductal adenocarcinoma

Alissandra L. Hillis, Allison N. Lau, Camille X. Devoe, Talya L. Dayton, Laura V. Danai, Dolores Di Vizio, Matthew G. Vander Heiden

Cancer & Metabolism · 2018 · 32 citations · 35 references

DOIFull text

Open access

Abstract

PKM2 is not required for initiation or growth of PDAC tumors arising in the KP<sup>-/-</sup>C pancreatic cancer model. These findings suggest that, in this mouse PDAC model, PKM2 expression is not required for pancreatic tumor formation or progression.

References

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

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PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Weiwei Yang, Yan Xia, David H. Hawke et al. · Cell · 2012 · 825 citations · Full text

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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

Xueliang Gao, Haizhen Wang, Jenny Yang et al. · Molecular Cell · 2012 · 752 citations · Full text

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