Concepedia

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease

Kenneth W. Drombosky, Sascha Rode, Ravi Kodali, Tija C. Jacob, Michael J. Palladino, Ronald Wetzel

Neurobiology of Disease · 2018 · 61 citations · 53 references

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References

53

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

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Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

Stephen W. Davies, Mark Turmaine, Barbara A. Cozens et al. · Cell · 1997 · 2.2K citations · Full text

, , +17

An optimized transgenesis system for <i>Drosophila</i> using germ-line-specific φC31 integrases

Johannes Bischof, Robert K. Maeda, Monika Hediger et al. · Proceedings of the National Academy of Sciences · 2007 · 2K citations · Full text

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Montserrat Arrasate, Siddhartha Mitra, Erik S. Schweitzer et al. · Nature · 2004 · 2K citations

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Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

Eberhard Scherzinger, Rudi Lurz, Mark Turmaine et al. · Cell · 1997 · 1.3K citations · Full text

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