Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Olga Martins de Brito, Luca Scorrano · Nature · 2008 · 2.3K citations

Biochemistry, Mitochondrial Dynamic, Natural Sciences +6

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, Eileen McGowan, Julia M. Rockwood et al. · Nature Genetics · 2000 · 1.3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Neurofibrillary Tangles +9

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

Naotada Ishihara, Masatoshi Nomura, Akihiro Jofuku et al. · Nature Cell Biology · 2009 · 1K citations

Developmental Biology, Synapse Formation, Mitochondrial Function +7

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kook Hwan Kim, Yeon Taek Jeong, Hyunhee Oh et al. · Nature Medicine · 2012 · 760 citations

Insulin Resistance, Metabolic Syndrome, Obesity +15

Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

Giovanna R. Mallucci, Andrew Dickinson, Jacqueline M. Linehan et al. · Science · 2003 · 751 citations

Creutzfeldt-jakob Disease, Immunology, Social Sciences +16