The Integrated Stress Response is a eukaryotic cellular signaling pathway that functions as a convergent regulator of translation and gene expression in response to diverse stress conditions by phosphorylating the alpha subunit of eukaryotic initiation factor 2, thereby selectively modulating translational initiation to restore cellular homeostasis.
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Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski, Diego Acosta‐Alvear, Arkady Khoutorsky et al. · eLife · 2013 · 743 citations · Full text
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