Concepedia

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

Eleonora Trotta, Paul Bessette, Stephanie Silveria, Lauren K. Ely, Kevin M. Jude, Duy T. Le, Charles R. Holst, Anthony J. Coyle, Marc Potempa, Lewis L. Lanier,

Nature Medicine · 2018 · 196 citations · 42 references

DOI

Concepts

References

42

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

, , +17

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

, , +16

Inference of Macromolecular Assemblies from Crystalline State

Evgeny Krissinel, Kim Henrick · Journal of Molecular Biology · 2007 · 10.4K citations · Full text

, , +14

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

, , +17

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

, , +17