Concepedia

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

Francesca Curreli, Dmitry S. Belov, Young Do Kwon, Ranjith Ramesh, Anna Furimsky, Kathleen O’Loughlin, Patricia C. Byrge, Lalitha Iyer, Jon C. Mirsalis, Alexander V. Kurkin,

European Journal of Medicinal Chemistry · 2018 · 42 citations · 54 references

DOIFull text

Open access

Concepts

References

54

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature · 1998 · 3K citations · Full text

, , +12

Antibody neutralization and escape by HIV-1

Xiping Wei, Julie M. Decker, Shuyi Wang et al. · Nature · 2003 · 2.4K citations

, , +12

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

Brandon F. Keele, Elena E. Giorgi, Jesus F. Salazar-Gonzalez et al. · Proceedings of the National Academy of Sciences · 2008 · 1.9K citations · Full text

, , +17

Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy

Xiping Wei, Julie M. Decker, Hongmei Liu et al. · Antimicrobial Agents and Chemotherapy · 2002 · 1.6K citations · Full text

, , +17

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

Ruth I. Connor, Benjamin K. Chen, Sunny Choe et al. · Virology · 1995 · 1.3K citations · Full text

, , +16