The transgenic chicken derived anti-CD20 monoclonal antibodies exhibits greater anti-cancer therapeutic potential with enhanced Fc effector functions

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Raphael Clynes, Terri L. Towers, Leonard G. Presta et al. · Nature Medicine · 2000 · 2.7K citations

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Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

Robert L. Shields, Jadine Lai, Rodney G. Keck et al. · Journal of Biological Chemistry · 2002 · 1.8K citations · Full text

Life Sciences, Biochemistry, Immunology +16

The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

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Medicine, Cancer Biology, Oncology +16

Germline transmission of genetically modified primordial germ cells

Marie‐Cecile van de Lavoir, Jennifer H. Diamond, Philip A. Leighton et al. · Nature · 2006 · 493 citations

Life Sciences, Developmental Biology, Genetics +14