Concepedia

Fc-mediated Effector Function Enhancement

Fc-Mediated Effector Function Enhancement is a glycoengineering strategy that specifically modifies the Fc region glycosylation of antibodies to augment their ability to recruit immune effector functions such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis.

177

Publications

15.5K

Citations

1.8K

Authors

412

Institutions

Publications per year

2017–2026

80

Parents

Publications

177

Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

Robert L. Shields, Jadine Lai, Rodney G. Keck et al. · Journal of Biological Chemistry · 2002 · 1.8K citations · Full text

, , +16

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Frederick Arce Vargas, Andrew J.S. Furness, Kevin Litchfield et al. · Cancer Cell · 2018 · 585 citations · Full text

, , +17

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

Stylianos Bournazos, Florian Klein, John Pietzsch et al. · Cell · 2014 · 504 citations · Full text

, , +10

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

Christian M. Karsten, Manoj K. Pandey, Julia Figge et al. · Nature Medicine · 2012 · 466 citations · Full text

, , +13

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

David J. DiLillo, Peter Palese, Patrick C. Wilson et al. · Journal of Clinical Investigation · 2016 · 428 citations · Full text

, , +14

1–5 of 177

Authors

1.8K

  1. MP
    Matthias Peipp

    Christian-Albrechts-Universität zu Kiel, Germany

    7 publications · 672 citations

    7

    h-index

  2. AF
    Andrés Finzi

    Université de Montréal, Canada

    7 publications · 666 citations

    7

    h-index

  3. GV
    Gestur Vidarsson

    Sanquin, Netherlands

    7 publications · 301 citations

    7

    h-index

  4. JV
    Jeffrey V. Ravetch

    Rockefeller University, United States

    6 publications · 1.5K citations

    6

    h-index

  5. TV
    Thomas Valerius

    Christian-Albrechts-Universität zu Kiel, Germany

    6 publications · 362 citations

    6

    h-index

1–5 of 1.8K

Institutions

412

  1. Rockefeller University

    New York, United States

    8 h-index

    27 publications

    5.4K citations

  2. Sanquin

    Amsterdam, Netherlands

    8 h-index

    52 publications

    2.1K citations

  3. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    8 h-index

    54 publications

    3.2K citations

  4. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    7 h-index

    25 publications

    3.8K citations

  5. Université de Montréal

    Montreal, Canada

    7 h-index

    45 publications

    6.2K citations

  6. McGill University

    Montreal, Canada

    7 h-index

    13 publications

    1.5K citations

  7. Centre Hospitalier de l’Université de Montréal

    Montreal, Canada

    7 h-index

    67 publications

    9.8K citations

  8. University of Pennsylvania

    Philadelphia, United States

    6 h-index

    25 publications

    1.2K citations

1–8 of 412

Venues

  1. The Journal of Immunology

    JI · 17 publications · 796 citations

    14

    h-index

  2. Frontiers in Immunology

    11 publications · 569 citations

    11

    h-index

  3. Blood

    8 publications · 710 citations

    8

    h-index

  4. mAbs

    7 publications · 447 citations

    7

    h-index

  5. Journal of Biological Chemistry

    JBC · 6 publications · 2.5K citations

    6

    h-index

1–5