Concepedia

Fc Effector Profiling

Fc Effector Profiling is a methodological framework in immunology that characterizes the functional capacity of the Fc region of antibodies to engage effector mechanisms such as antibody-dependent cellular cytotoxicity, phagocytosis, and complement activation, thereby distinguishing it from other antibody profiling approaches by its specific focus on Fc-mediated downstream immune activities.

9

Publications

569

Citations

104

Authors

37

Institutions

Publications per year

2017–2026

4

Parents

Publications

9

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Manfred Wuhrer, Maurice H. J. Selman, Liam A. McDonnell et al. · Journal of Neuroinflammation · 2015 · 103 citations · Full text

, , +17

Different Adaptations of IgG Effector Function in Human and Nonhuman Primates and Implications for Therapeutic Antibody Treatment

Max Warncke, Thomas Calzascia, M. Coulot et al. · The Journal of Immunology · 2012 · 98 citations

, , +13

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for FcγR2a and FcγR2b

Margaret E. Ackerman, Anne‐Sophie Dugast, Elizabeth McAndrew et al. · Journal of Virology · 2013 · 95 citations · Full text

, , +17

Development of a robust reporter-based ADCC assay with frozen, thaw-and-use cells to measure Fc effector function of therapeutic antibodies

Zhi-jie Jey Cheng, Denise Garvin, Aileen Paguio et al. · Journal of Immunological Methods · 2014 · 79 citations

, , +14

A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus

Bronwyn M. Gunn, Richard Lu, Matthew D. Slein et al. · Immunity · 2021 · 67 citations · Full text

, , +17

1–5 of 9

Authors

104

  1. GA
    Galit Alter

    Ragon Institute of MGH, MIT and Harvard, United States

    4 publications · 241 citations

    4

    h-index

  2. EO
    Erica Ollmann Saphire

    Scripps Research Institute, United States

    3 publications · 146 citations

    3

    h-index

  3. KB
    Kathryn Bowman

    Ragon Institute of MGH, MIT and Harvard, United States

    2 publications · 79 citations

    2

    h-index

  4. SL
    Sharon L. Schendel

    La Jolla Institute for Immunology, United States

    2 publications · 101 citations

    2

    h-index

  5. CA
    Caroline Atyeo

    Ragon Institute of MGH, MIT and Harvard, United States

    2 publications · 101 citations

    2

    h-index

1–5 of 104

Institutions

37

  1. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    4 h-index

    27 publications

    1.7K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    11 publications

    762 citations

  3. La Jolla Institute for Immunology

    San Diego, United States

    3 h-index

    6 publications

    281 citations

  4. Komipharm International (South Korea)

    Incheon, South Korea

    1 h-index

    1 publications

    27 citations

  5. Munich Cluster for Systems Neurology

    Munich, Germany

    1 h-index

    1 publications

    103 citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    1 h-index

    3 publications

    201 citations

  7. Tulane University

    New Orleans, United States

    1 h-index

    2 publications

    134 citations

  8. Duke University Hospital

    Durham, United States

    1 h-index

    1 publications

    34 citations

1–8 of 37

Venues

  1. Journal of Neuroinflammation

    JNI · 1 publications · 103 citations

    1

    h-index

  2. Journal of Immunological Methods

    1 publications · 79 citations

    1

    h-index

  3. Immunity

    1 publications · 67 citations

    1

    h-index

  4. Methods in molecular biology

    Book series · 1 publications · 21 citations

    1

    h-index

  5. The Journal of Immunology

    JI · 1 publications · 98 citations

    1

    h-index

1–5