Concepedia

Effector Function Modulation

Effector Function Modulation is an antibody engineering strategy that involves rationally altering an antibody’s Fc region or overall architecture to enhance, attenuate, or reprogram its interactions with immune effector pathways such as Fc receptor engagement and complement activation, thereby tuning downstream immune responses.

140

Publications

10.6K

Citations

1.2K

Authors

337

Institutions

Publications per year

2017–2026

45

Variants

Effector Function Engineering

Parents

Children

Publications

140

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Robert L. Shields, Angela K. Namenuk, Kyu Hong et al. · Journal of Biological Chemistry · 2001 · 1.2K citations · Full text

, , +17

Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents

Mark S. Cragg, Martin J. Glennie · Blood · 2003 · 358 citations

, , +16

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Megan Lo, Hok Seon Kim, Raymond K. Tong et al. · Journal of Biological Chemistry · 2017 · 330 citations · Full text

, , +16

Modulating IgG effector function by Fc glycan engineering

Tiezheng Li, David J. DiLillo, Stylianos Bournazos et al. · Proceedings of the National Academy of Sciences · 2017 · 328 citations · Full text

, , +17

Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells

John O. Richards, Sher Karki, Greg A. Lazar et al. · Molecular Cancer Therapeutics · 2008 · 304 citations

, , +17

1–5 of 140

Authors

1.2K

  1. MP
    Matthias Peipp

    Christian-Albrechts-Universität zu Kiel, Germany

    5 publications · 620 citations

    5

    h-index

  2. TV
    Thomas Valerius

    Christian-Albrechts-Universität zu Kiel, Germany

    5 publications · 396 citations

    5

    h-index

  3. LW
    Lai‐Xi Wang

    University of Maryland, Baltimore, United States

    5 publications · 758 citations

    5

    h-index

  4. FN
    Falk Nimmerjahn

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    4 publications · 448 citations

    4

    h-index

  5. YG
    Y. Gloria Meng

    Gene Therapy Laboratory, France

    4 publications · 1.5K citations

    4

    h-index

1–5 of 1.2K

Institutions

337

  1. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    7 h-index

    40 publications

    3K citations

  2. Kyowa Kirin (Japan)

    Tokyo, Japan

    7 h-index

    13 publications

    1.1K citations

  3. University of Maryland, College Park

    College Park, United States

    6 h-index

    14 publications

    1.8K citations

  4. Inserm

    Paris, France

    6 h-index

    32 publications

    1.9K citations

  5. Rockefeller University

    New York, United States

    5 h-index

    19 publications

    2.6K citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    5 h-index

    24 publications

    1.6K citations

  7. University of Oxford

    Oxford, United Kingdom

    4 h-index

    7 publications

    992 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    4 h-index

    10 publications

    226 citations

1–8 of 337

Venues

  1. The Journal of Immunology

    JI · 14 publications · 938 citations

    14

    h-index

  2. Journal of Biological Chemistry

    JBC · 9 publications · 1.7K citations

    9

    h-index

  3. mAbs

    7 publications · 343 citations

    7

    h-index

  4. Blood

    6 publications · 782 citations

    6

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 960 citations

    6

    h-index

1–5