Pimentelamines A–C, Indole Alkaloids Isolated from the Leaves of the Australian Tree <i>Flindersia pimenteliana</i>

Abstract

Three members of a new class of ascorbic acid-adduct indole alkaloids ( 1 – 3 ), a new prenylated indole alkaloid ( 4 ), and five known compounds ( 5 – 9 ) were isolated from the leaves of Flindersia pimenteliana . The structures of 1 – 4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC 50 values ranging from 0.19 to 3.6 μM.