Concepedia

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

Houjun Xia, Wei Wang, Joel Crespo, Ilona Kryczek, Wei Li, Shuang Wei, Zhaoqun Bian, Tomasz Maj, Ming‐Xiao He, J Rebecca Liu,

Science Immunology · 2017 · 149 citations · 34 references

DOI

Concepts

Abstract

Tumor-derived lactate induced naïve T cell apoptosis via suppressing FIP200 expression and autophagy formation, resulting in mitochondria activation and imbalance of Bcl-2 family members in T cells.

References

34

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih‐Hao Chang, Jing Qiu, David O’Sullivan et al. · Cell · 2015 · 3.2K citations · Full text

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo et al. · Nature · 2014 · 2.9K citations

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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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