Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Deborah J. Veis, Christine M. Sorenson, John R. Shutter, +1

Cell

Autoimmune DiseaseApoptosisImmunologyPathologyCell Death +5

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

Charles L. Sentman, John R. Shutter, David M. Hockenbery, +2

Cell

Lymphocyte DevelopmentApoptosisImmunologyCell DeathImmunologic Mechanism +5

Notch signaling is essential for vascular morphogenesis in mice

Luke T. Krebs, Yingzi Xue, Christine R. Norton, +10

Genes & Development

Developmental BiologyAngiogenesisMedicineGeneticsNatural Sciences +12

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

Stanley J. Korsmeyer, John R. Shutter, Deborah J. Veis, +2

PubMed

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

John R. Shutter, Melissa Graham, Alfred C. Kinsey, +3

Genes & Development

Novel GeneMurine HomologGeneticsGene CharacterizationObesity +20

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Luke T. Krebs, John R. Shutter, Kenji Tanigaki, +3

Genes & Development

Rbpsuh GeneGeneticsVascular MalformationHaploinsufficient LethalityTranscriptional Regulation +17

<i>Dll4, </i>a novel Notch ligand expressed in arterial endothelium

John R. Shutter, Sheila Scully, Wei Fan, +5

Genes & Development

Hox11 controls the genesis of the spleen

Charles W.M. Roberts, John R. Shutter, Stanley J. Korsmeyer

Nature

Lymphocyte DevelopmentPathogenesisHematologyLymphatic SystemPathology +1

Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors

Marta Letizia Hribal, Jun Nakae, Tadahiro Kitamura, +2

The Journal of Cell Biology

Insulin-like Growth FactorsInsulin SignalingTranscriptional RegulationSignaling PathwayCell Regulation +14

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

Varman T. Samuel, Cheol Soo Choi, Trevor G. Phillips, +9

Diabetes

Glucose ToleranceInsulin SignalingOxidative StressObesityMetabolic Syndrome +18