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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Zhijun Guo, Irina F. Sevrioukova, Ilia G. Denisov, Xia Zhang, Ting-Lan Chiu, Dafydd G. Thomas, Eric A. Hanse, Rebecca A. D. Cuellar, Yelena V. Grinkova, Vanessa Wankhede Langenfeld,

Cell chemical biology · 2017 · 52 citations · 44 references

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44

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology · 2011 · 7K citations · Full text

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Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

Mohamad-Yehia El-Mir, Véronique Nogueira, Éric Fontaine et al. · Journal of Biological Chemistry · 2000 · 1.4K citations · Full text

, , +17

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi et al. · Nature · 2014 · 1.3K citations

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Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

William W. Wheaton, Samuel E. Weinberg, Robert B. Hamanaka et al. · eLife · 2014 · 1.1K citations · Full text

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Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

Mahvash Zakikhani, Ryan J.O. Dowling, I. George Fantus et al. · Cancer Research · 2006 · 1K citations · Full text

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