Concepedia

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi, Xian‐Man Zhang, Demetrios T. Braddock, Ronald A. Albright, Brett J. Prigaro, John L. Wood, Sanjay Bhanot, Michael J. MacDonald,

Nature · 2014 · 1.3K citations · 32 references

DOI

Concepts

References

32

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

, , +17

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

, , +17

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

DH Williamson, P. Kay Lund, HA Krebs · Biochemical Journal · 1967 · 1.9K citations · Full text

, , +16

Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

Mohamad-Yehia El-Mir, Véronique Nogueira, Éric Fontaine et al. · Journal of Biological Chemistry · 2000 · 1.4K citations · Full text

, , +17