The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

Henrique Borges da Silva, Lalit K. Beura, Haiguang Wang, +14

Nature

Immunological MemoryMolecular PhysiologySignal TransductionAdaptive Immune SystemT-regulatory Cell +8

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

Thai Q. Tran, Eric A. Hanse, Amber N. Habowski, +9

Nature Cancer

Cancer ResearchOncologyMedicineColorectal CancerPathology +6

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Benjamin A. Olenchock, Javid J. Moslehi, Alan H. Baik, +13

Cell

α-Ketoglutarate SufficeEgln1 InhibitionMedicineImmunologyGlycobiology +3

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, +9

Nature Communications

Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer

Eric A. Hanse, Chunhai Ruan, Maureen Kachman, +3

Oncogene

Tumor BiologyCellular EnzymologyBiochemistryMedicineNatural Sciences +9

Digital transcriptome analysis indicates adaptive mechanisms in the heart of a hibernating mammal

Katharine M. Brauch, Nirish Dhruv, Eric A. Hanse, +1

Physiological Genomics

Cardiac MuscleGeneticsTranscriptomics TechnologyGene CharacterizationGenomics +18

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

Xazmin H. Lowman, Eric A. Hanse, Ying Yang, +4

Cell Reports

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Mari B. Ishak Gabra, Ying Yang, Haiqing Li, +9

Nature Communications

Distinct proliferative and transcriptional effects of the D-type cyclins in vivo

Lisa K. Mullany, Peter White, Eric A. Hanse, +7

Cell Cycle

Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration

Jingmin Shu, Betsy T. Kren, Zhilian Xia, +9

Hepatology