Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

Sulforhodamine B colorimetric assay for cytotoxicity screening

Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols · 2006 · 3.6K citations

Cytotoxicity Screening, Medicine, Toxicology +3

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Sunil R. Hingorani, Lifu Wang, Asha S. Multani et al. · Cancer Cell · 2005 · 2.6K citations · Full text

Genome Instability, Pancreatic Cancer, Chromosomal Instability +7

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

Drug Target, Signal Transduction, Medicine +6

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos et al. · Nature · 2013 · 2.4K citations · Full text

Molecular Pharmacology, Signal Transduction, G Protein-coupled Receptor +7

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj, Chang‐Il Hwang, Lindsey A. Baker et al. · Cell · 2014 · 2.1K citations · Full text

Tumor Biology, Pancreatic Cancer, Pathology +4