Concepedia

Polo-like Kinase Function

Polo-Like Kinase Function is a regulatory protein kinase activity that governs key events in mitotic progression, including centrosome maturation, spindle assembly, and cytokinesis, through phosphorylation of substrate proteins involved in cell cycle control.

1.3K

Publications

91K

Citations

7K

Authors

1.5K

Institutions

Publications per year

2017–2026

324

Parents

Publications

1.3K

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Martin Steegmaier, Matthias Hoffmann, Anke Baum et al. · Current Biology · 2007 · 849 citations · Full text

, , +14

The Polo kinase Plk4 functions in centriole duplication

Robert Habedanck, York‐Dieter Stierhof, Christopher J. Wilkinson et al. · Nature Cell Biology · 2005 · 810 citations

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The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain

Andrew E. H. Elia, Peter Rellos, L.F. Haire et al. · Cell · 2003 · 769 citations · Full text

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Libor Macůrek, Arne Lindqvist, Dan Lim et al. · Nature · 2008 · 711 citations

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

Heidi A. Lane, Erich A. Nigg · The Journal of Cell Biology · 1996 · 690 citations · Full text

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Authors

7K

  1. EA
    Erich A. Nigg

    Max Planck Institute of Biochemistry, Germany

    34 publications · 7.6K citations

    33

    h-index

  2. RL
    Raymond L. Erikson

    Harvard University, United States

    27 publications · 3.7K citations

    25

    h-index

  3. KS
    Kyung S. Lee

    National Cancer Institute, United States

    35 publications · 2.5K citations

    24

    h-index

  4. WD
    Wei Dai

    New York University, United States

    26 publications · 1.7K citations

    23

    h-index

  5. KS
    Klaus Strebhardt

    Goethe University Frankfurt, Germany

    31 publications · 2.7K citations

    23

    h-index

1–5 of 7K

Institutions

1.5K

  1. Harvard University

    Cambridge, United States

    37 h-index

    119 publications

    15.9K citations

  2. National Institutes of Health

    Bethesda, United States

    34 h-index

    211 publications

    10.9K citations

  3. Center for Cancer Research

    Bethesda, United States

    31 h-index

    192 publications

    18K citations

  4. National Cancer Institute

    Bethesda, United States

    29 h-index

    194 publications

    11.7K citations

  5. Goethe University Frankfurt

    Frankfurt am Main, Germany

    29 h-index

    205 publications

    11.9K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    29 h-index

    103 publications

    19.9K citations

  7. Heidelberg University

    Heidelberg, Germany

    28 h-index

    167 publications

    13.2K citations

  8. Max Planck Institute of Biochemistry

    Martinsried, Germany

    28 h-index

    87 publications

    17.8K citations

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Venues

  1. Journal of Biological Chemistry

    JBC · 101 publications · 7.3K citations

    47

    h-index

  2. The Journal of Cell Biology

    JCB · 48 publications · 6.5K citations

    38

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 43 publications · 5.5K citations

    37

    h-index

  4. Cell Cycle

    73 publications · 2.6K citations

    33

    h-index

  5. Journal of Cell Science

    45 publications · 3.3K citations

    32

    h-index

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