Science · 2017 · 232 citations · 23 references
MedicineCancer BiologyMolecular BiologyCell SignalingMolecular OncologySignal TransductionCancer Cell SignalingCancer MetabolismMetabolic ReprogrammingMetabolic Reprogramming In CancerOncogenic Signaling PathwaysSignal Transduction In CancerCellular Metabolic AdaptationMtor Complex 1 RegulationMtor Complex 1 SignalingMtor SignalingMtorc1 SignalingRag Gtpase SignalingTranscriptional ActivationTranscriptional Regulatory Networks
genes in cells and tissues from patients and murine models of renal cell carcinoma, pancreatic ductal adenocarcinoma, and melanoma triggered RagD-mediated mTORC1 induction, resulting in cell hyperproliferation and cancer growth. Thus, this transcriptional regulatory mechanism enables cellular adaptation to nutrient availability and supports the energy-demanding metabolism of cancer cells.
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