Concepedia

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection

Xin Niu, Hetal Brahmbhatt, Philipp Mergenthaler, Zhi Zhang, Jing Sang, Michael Daude, Fabian G. R. Ehlert, Wibke E. Diederich, Eve Wong, Weijia Zhu,

Cell chemical biology · 2017 · 93 citations · 49 references

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49

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Simon N. Willis, Jamie I. Fletcher, Thomas Kaufmann et al. · Science · 2007 · 1.1K citations

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy

Christian Tovar, James Rosinski, Zoran Filipovic et al. · Proceedings of the National Academy of Sciences · 2006 · 703 citations · Full text

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Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

Yi‐Te Hsu, Richard J. Youle · Journal of Biological Chemistry · 1997 · 592 citations · Full text

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Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E. Czabotar, Dana Westphal, Grant Dewson et al. · Cell · 2013 · 574 citations · Full text

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Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Jonathan F. Lovell, Lieven P. Billen, Scott Bindner et al. · Cell · 2008 · 558 citations · Full text

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