Concepedia

Bak Oligomerization

Bak Oligomerization is a molecular mechanism in mitochondrial outer membrane permeabilization wherein activated Bak proteins undergo conformational changes and assemble into higher-order oligomeric complexes that directly induce membrane porosity and initiate apoptotic signaling.

66

Publications

7.7K

Citations

390

Authors

140

Institutions

Publications per year

2017–2026

15

Parents

Publications

66

VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

Emily H. Cheng, Tatiana Sheiko, Jill K. Fisher et al. · Science · 2003 · 825 citations

, , +14

Role of Bax and Bak in mitochondrial morphogenesis

Mariusz Karbowski, Kristi L. Norris, Megan M. Cleland et al. · Nature · 2006 · 611 citations

, , +12

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

Susan Erster, Motohiro Mihara, Roger H. Kim et al. · Molecular and Cellular Biology · 2004 · 368 citations · Full text

, , +17

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

Grant Dewson, Ruth M. Kluck · Journal of Cell Science · 2009 · 354 citations · Full text

, , +16

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

Grant Dewson, Tobias Kratina, Huiyan W. Sim et al. · Molecular Cell · 2008 · 336 citations · Full text

, , +11

1–5 of 66

Authors

390

  1. RM
    Ruth M. Kluck

    Walter and Eliza Hall Institute of Medical Research, Australia

    11 publications · 1.5K citations

    11

    h-index

  2. GD
    Grant Dewson

    Walter and Eliza Hall Institute of Medical Research, Australia

    11 publications · 1.5K citations

    11

    h-index

  3. AE
    Amber E. Alsop

    Walter and Eliza Hall Institute of Medical Research, Australia

    5 publications · 271 citations

    5

    h-index

  4. RC
    Ray C. Bartolo

    The University of Melbourne, Australia

    4 publications · 390 citations

    4

    h-index

  5. HD
    Haiming Dai

    Mayo Clinic, United States

    4 publications · 341 citations

    4

    h-index

1–5 of 390

Institutions

140

  1. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    12 h-index

    79 publications

    8.6K citations

  2. The University of Melbourne

    Melbourne, Australia

    7 h-index

    51 publications

    3.8K citations

  3. Rosalind Franklin University of Medicine and Science

    North Chicago, United States

    4 h-index

    23 publications

    1.6K citations

  4. National Institutes of Health

    Bethesda, United States

    4 h-index

    8 publications

    3.2K citations

  5. Mayo Clinic

    Rochester, United States

    4 h-index

    22 publications

    1.9K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    8 publications

    4.5K citations

  7. University of Utah

    Salt Lake City, United States

    3 h-index

    6 publications

    315 citations

  8. McGill University

    Montreal, Canada

    3 h-index

    6 publications

    1.2K citations

1–8 of 140

Venues

  1. Journal of Biological Chemistry

    JBC · 11 publications · 1.2K citations

    11

    h-index

  2. Molecular Cell

    6 publications · 1.5K citations

    6

    h-index

  3. PLoS ONE

    3 publications · 140 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 347 citations

    3

    h-index

  5. Biophysical Journal

    3 publications · 81 citations

    3

    h-index

1–5