Zoran Filipovic

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy

Christian Tovar, James Rosinski, Zoran Filipovic et al. · Proceedings of the National Academy of Sciences · 2006 · 703 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 661 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Qingjie Ding, Zhuming Zhang, Jinjun Liu et al. · Journal of Medicinal Chemistry · 2013 · 597 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models

Christian Tovar, Bradford Graves, Kathryn Packman et al. · Cancer Research · 2013 · 285 citations

Medicine, Oncology, Pharmacology +14