Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood

Yong S. Chang, Emmanuelle di Tomaso, Donald M. McDonald, +3

Proceedings of the National Academy of Sciences

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais, +23

Proceedings of the National Academy of Sciences

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models

Yong S. Chang, Jalila Adnane, Pamela A. Trail, +12

Cancer Chemotherapy and Pharmacology

OncologyMedicineTumor GrowthCell DeathRcc Xenograft Models +8

Shear stress increases hydraulic conductivity of cultured endothelial monolayers

Howard W. Sill, Yong S. Chang, J. R. Artman, +3

American Journal of Physiology-Heart and Circulatory Physiology

Effect of Vascular Endothelial Growth Factor on Cultured Endothelial Cell Monolayer Transport Properties

Yong S. Chang, Lance L. Munn, Mechteld Hillsley, +6

Microvascular Research

AngiogenesisVascular AdaptationEndothelial DysfunctionVascular BiologyBiomedical Engineering +7

Shear stress regulates occludin content and phosphorylation

Lucas DeMaio, Yong S. Chang, Thomas W. Gardner, +2

American Journal of Physiology-Heart and Circulatory Physiology

Cell AdhesionCellular PhysiologyBlood FlowHydraulic ConductivityCell Signaling +15

Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

Jin Gao, Jon Chesebrough, Susan A. Cartlidge, +10

Cancer Research

Insulin-like Growth FactorsTumor GrowthMedicineImmunologyTumor Immunity +12

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development

Vincent Guerlavais, Tomi K. Sawyer, Luis A. Carvajal, +16

Journal of Medicinal Chemistry

A Systematic Approach for Developing Bacteria-Specific Imaging Tracers

Alvaro A. Ordoñez, Edward A. Weinstein, Lauren E. Bambarger, +10

Journal of Nuclear Medicine

Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo

Alyssa G. Ashbaugh, Xuesong Jiang, Jesse Zheng, +14

Proceedings of the National Academy of Sciences

EngineeringBiomimetic MaterialsBiomaterials DesignBiomedical EngineeringBiofilms +21