Dana Westphal

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E. Czabotar, Dana Westphal, Grant Dewson et al. · Cell · 2013 · 574 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Jason M. Brouwer, Dana Westphal, Grant Dewson et al. · Molecular Cell · 2014 · 158 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal, Grant Dewson, Marie Ménard et al. · Proceedings of the National Academy of Sciences · 2014 · 122 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases <i>In Vitro</i> and <i>In Vivo</i>

Heike Niessner, Jennifer Schmitz, Ghazaleh Tabatabai et al. · Clinical Cancer Research · 2016 · 100 citations

Medicine, Oncology, Pharmacology +17

The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis

Cedric Tehranian, Laura Fankhauser, Patrick N. Harter et al. · Neuro-Oncology · 2021 · 91 citations · Full text

Medicine, Oncology, Pharmacology +17