Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

Pharmacy, Pharmaceutics, Pharmacology +16

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

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Pharmacy, Oncology, Pharmacology +17

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2) –Positive Breast Cancer After Prior HER2-Directed Therapy

Howard A. Burris, Hope S. Rugo, Svetislava J. Vukelja et al. · Journal of Clinical Oncology · 2010 · 764 citations · Full text

Pharmacy, Oncology, Pharmacology +17

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Robert P. Lyon, Jocelyn R. Setter, Tim D. Bovee et al. · Nature Biotechnology · 2014 · 445 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

Mark E. B. Smith, Felix Schumacher, Chris P. Ryan et al. · Journal of the American Chemical Society · 2010 · 374 citations · Full text

Life Sciences, Biochemistry, Bioorthogonal Chemistry +12