Jocelyn R. Setter

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

Robert P. Lyon, Tim D. Bovee, Svetlana O. Doronina et al. · Nature Biotechnology · 2015 · 498 citations

Medicinal Chemistry, Polymer-drug Conjugate, Medicine +8

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Robert P. Lyon, Jocelyn R. Setter, Tim D. Bovee et al. · Nature Biotechnology · 2014 · 430 citations

Pharmaceutical Science, Biochemistry, Polymer-drug Conjugate +9

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

Li Fu, Kim K. Emmerton, Mechthild Jonas et al. · Cancer Research · 2016 · 302 citations

Immunology, Immunotherapy, Tumor Biology +16

Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues

Robert P. Lyon, David L. Meyer, Jocelyn R. Setter et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 2011 · 106 citations

Medicinal Chemistry, Drug Targeting, Medicine +8

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

A.E. Prota, Jocelyn R. Setter, Andrew B. Waight et al. · Journal of Molecular Biology · 2016 · 78 citations · Full text

Molecular Biology, Cytoskeleton, Inhibit Microtubule Formation +3