João P. M. Nunes

Next generation maleimides enable the controlled assembly of antibody–drug conjugates<i>via</i>native disulfide bond bridging

Felix Schumacher, João P. M. Nunes, Antoine Maruani et al. · Organic & Biomolecular Chemistry · 2014 · 166 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmaceutics +17

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

João P. M. Nunes, Maurício Morais, Vessela Vassileva et al. · Chemical Communications · 2015 · 113 citations · Full text

Pharmacy, Biochemistry, Pharmaceutics +17

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

E. Robinson, João P. M. Nunes, Vessela Vassileva et al. · RSC Advances · 2017 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmaceutics +15

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Maurício Morais, João P. M. Nunes, Kersti Karu et al. · Organic & Biomolecular Chemistry · 2017 · 69 citations · Full text

Pharmacy, Biochemistry, Chemical Biology +17

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Mark E. B. Smith, Mikael B. Caspersen, E. Robinson et al. · Organic & Biomolecular Chemistry · 2015 · 64 citations · Full text

Life Sciences, Biochemistry, Biotechnology +10