Concepedia

BIN1localization is distinct from Tau tangles in Alzheimer’s disease

Pierre De Rossi, Virginie Buggia-Prévot, Robert J. Andrew, Sofia V. Krause, Elizabeth Woo, Peter T. Nelson, Peter Pytel, Gopal Thinakaran

Matters · 2017 · 25 citations · 10 references

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Concepts

Abstract

BIN1 expression can be observed in a subset of neurons in the AD brain. Further investigations are warranted to understand the complex cellular mechanisms underlying the observed correlation between BIN1 expression and the severity of tangle pathology in AD.

References

10

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Ye Zhang, Kenian Chen, Steven A. Sloan et al. · Journal of Neuroscience · 2014 · 5.4K citations · Full text

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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Ye Zhang, Steven A. Sloan, Laura Clarke et al. · Neuron · 2015 · 2.5K citations · Full text

, , +14

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Katherine R. Sadleir, Patty C. Kandalepas, Virginie Buggia-Prévot et al. · Acta Neuropathologica · 2016 · 296 citations · Full text

, , +17

Loss of Bin1 Promotes the Propagation of Tau Pathology

Sara Calafate, William P. Flavin, Patrik Verstreken et al. · Cell Reports · 2016 · 279 citations · Full text

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Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L.L. Clayton et al. · Molecular Neurodegeneration · 2016 · 170 citations · Full text

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