Katherine R. Sadleir

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

Tracy O’Connor, Katherine R. Sadleir, Erika Maus et al. · Neuron · 2008 · 418 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

Ji‐Yeun Hur, Georgia Frost, Xianzhong Wu et al. · Nature · 2020 · 394 citations · Full text

Life Sciences, Immunology, Neuroscience +14

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Katherine R. Sadleir, Patty C. Kandalepas, Virginie Buggia-Prévot et al. · Acta Neuropathologica · 2016 · 296 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

Patty C. Kandalepas, Katherine R. Sadleir, William A. Eimer et al. · Acta Neuropathologica · 2013 · 241 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

Katherine R. Sadleir, William A. Eimer, Sarah L. Cole et al. · Molecular Neurodegeneration · 2015 · 212 citations · Full text

Life Sciences, Neurology, Neuroscience +17