SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

Ru Cao, Liangjun Wang, Hengbin Wang et al. · Science · 2002 · 3.7K citations

Histone Modifications, Epigenetic Change, Genetics +17

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou et al. · Nature · 2002 · 2.7K citations · Full text

Tumor Biology, Chromatin, Chromatin Structure +8

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

Cell Regulation, Pten-deficient Tumorigenesis, Crucial Role +10

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

Signal Transduction, Cell Regulation, Molecular Pathway +11

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations

Ubiquitin-mediated Degradation, Signal Transduction, Cell Regulation +9