Avram Hershko

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +12

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

Avram Hershko, H Heller, Sarah Elias et al. · Journal of Biological Chemistry · 1983 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Valery Sudakin, D Ganoth, Aviva Dahan et al. · Molecular Biology of the Cell · 1995 · 755 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

Avram Hershko, Aaron Ciechanover, H Heller et al. · Proceedings of the National Academy of Sciences · 1980 · 747 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

The ubiquitin system

Avram Hershko, Aaron Ciechanover, A Varshavsky · Nature Medicine · 2000 · 650 citations