The Preservation of Proteins by Drying, with Special Reference to the Production of Dried Human Serum and Plasma for Transfusion

Abstract

Increasing use of proteins in biologic research and their rapid adoption in therapy have focused attention on the problems concerned with the handling of proteins. If protein preparations are to have a wide clinical use distribution must be made in a convenient and stable form which permits adequate standardization and insures reproducible results. A notable contribution to this requirement is the development of methods for reducing proteins to the dry state with a minimum of alteration in chemical or biologic properties. This book presents the application of vacuum drying from the frozen state to the problem of protein preservation. The author has made important contributions to the field and presents here the results of his own research together with the application to the large scale drying of human serum and plasma during the past six years in England. He reports on the drying of over 350,000 units of plasma and