Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz, +9

The Journal of Immunology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, +19

Nature Medicine

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineNlrp3 Inflammasome +12

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Yun‐Hee Youm, Kim Nguyen, Ryan W. Grant, +14

Nature Medicine

InflammationMedicineImmunologyInflammation BiologyChronic Inflammation +4

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun‐Shik Lee, Naeha Subramanian, Andrew I. Kim, +6

Nature

InflammationSignal TransductionMolecular PhysiologySignaling PathwayPhysiology +10

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Teresa Fernandes‐Alnemri, Jiang Wu, Je‐Wook Yu, +6

Cell Death and Differentiation

InflammationAnti-inflammatorySignal TransductionSupramolecular AssemblyApoptosis +9

Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids

Kenjiro Tadera, Yuji Minami, Kouta TAKAMATSU, +1

Journal of Nutritional Science and Vitaminology

PolyphenolicsBiosynthesisYeast Alpha-glucosidaseBiochemistryMedicine +6

Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>κ</mml:mi></mml:math>B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E2"><mml:mi>κ</mml:mi></mml:math>B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages

Mari Hämäläinen, Riina Nieminen, Pia Vuorela, +2

Mediators of Inflammation

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Christine A. Juliana, +10

Nature Immunology

InflammationAim2 InflammasomeHost ResponsePathogenesisImmunology +6

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

Franz Bauernfeind, Eva Bartok, Anna Rieger, +3

The Journal of Immunology

Lipid PeroxidationImmunologyCell DeathReactive Oxygen SpeciesRedox Biology +16

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Hideki Hara, K. Tsuchiya, Ikuo Kawamura, +7

Nature Immunology

Adaptor AscSignal TransductionSignaling PathwayMedicineMolecular Biology +7