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Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Death-inducing Signaling ComplexSignal TransductionProtein FunctionCryo-em StructureSignaling PathwayMedicineNatural SciencesApoptosisRegulation MechanismsCell DeathMolecular BiologyCellular BiochemistryCell Death MechanismsCell BiologyCell SignalingCellular PhysiologyMulti-protein AssemblyMolecular Signaling