Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, +10

Nature

InflammationCytokineMature Interleukin-1ImmunologyInnate Immunity +6

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Yu-Ru Lee, Ming Chen, Jonathan D. Lee, +24

Science

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

Chen Shen, Runzhi Li, Roberto Negro, +11

Cell

Viral ReplicationNatural SciencesRna BiologyMolecular BiologyVirology +6

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

Heng Ru, Melissa G. Chambers, Tian‐Min Fu, +2

Cell

Signal TransductionMolecular MechanismMolecular BiologyMedicineMulti-protein Assembly +2

Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold

Pietro Fontana, Ying Dong, Xiong Pi, +5

Science

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

Qingshan Fu, Tian‐Min Fu, Anthony Cruz, +6

Molecular Cell

Signal TransductionG Protein-coupled ReceptorNatural SciencesCell TraffickingApoptosis +13

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Tian‐Min Fu, Yang Li, Alvin Lu, +10

Molecular Cell

Death-inducing Signaling ComplexSignal TransductionProtein FunctionCryo-em StructureSignaling Pathway +13

Structures and gating mechanism of human TRPM2

Longfei Wang, Tian‐Min Fu, Yiming Zhou, +3

Science

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Alvin Lu, Yang Li, Florian I. Schmidt, +6

Nature Structural & Molecular Biology

Caspase-1 PolymerizationEngineeringBiochemistryNatural SciencesPolymer Science +7

Remote sensed and in situ constraints on processes affecting tropical tropospheric ozone

Bastien Sauvage, Randall V. Martin, Aaron van Donkelaar, +6

Atmospheric chemistry and physics

Upper AtmosphereMeteorologySitu ConstraintsEngineeringAtmospheric Interaction +10