Chen Shen

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Yu-Ru Lee, Ming Chen, Jonathan D. Lee et al. · Science · 2019 · 329 citations

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

Liudmila Andreeva, Liron David, Shaun Rawson et al. · Cell · 2021 · 248 citations · Full text

Nlrp3 Cages, Signal Transduction, Signaling Pathway +8

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

Chen Shen, Runzhi Li, Roberto Negro et al. · Cell · 2021 · 204 citations · Full text

Viral Replication, Natural Sciences, Rna Biology +8

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

Yang Li, Tian‐Min Fu, Alvin Lu et al. · Proceedings of the National Academy of Sciences · 2018 · 147 citations · Full text

Structural basis for the inhibition of Polo-like kinase 1

Jun Xu, Chen Shen, Tao Wang et al. · Nature Structural & Molecular Biology · 2013 · 120 citations

Signal Transduction, Signaling Pathway, Medicine +4